Cisplatin induced nephrotoxicity mechanism
WebMar 13, 2024 · Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe … WebJan 3, 2024 · Chemotherapy nephrotoxicity and dose modification in patients with kidney impairment: Molecularly targeted agents and immunotherapies; Cisplatin nephrotoxicity; Classic Kaposi sarcoma: Clinical features, staging, diagnosis, and treatment; Contrast-associated and contrast-induced acute kidney injury: Clinical features, diagnosis, and …
Cisplatin induced nephrotoxicity mechanism
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WebCisplatin is a widely used and highly effective cancer chemotherapeutic agent. One of the limiting side effects of cisplatin use is nephrotoxicity. Research over the past 10 years … WebOct 29, 2024 · There is evidence though that necrosis, oxidative stress, inflammation, and apoptosis may play crucial roles in cisplatin-induced nephrotoxicity 5. Cisplatin-induced nephrotoxicity...
http://www.bccancer.bc.ca/drug-database-site/Drug%20Index/Cisplatin_monograph.pdf WebOct 5, 2014 · The disproportionate accumulation of cisplatin in kidney tissue contributes to cisplatin-induced nephrotoxicity (Arany and Safirstein, 2003). Biosynthesis of amino acid lysine and methionine yields a quaternary ammonium compound called Carnitine, which is required for the transport of fatty acids from the cytosol into the mitochondria during ...
WebThe manufacturer recommends that an alerting mechanism be instituted to verify any order for cisplatin >100 mg/m. 2. per course every 3-4 weeks. ... induced diuresis to effectively decrease cisplatin-induced nephrotoxicity. 7. Refer to protocol by which patient is being treated. Numerous hydration regimens exist. WebCisplatin-induced nephrotoxicity is a major adverse event (AE), and the incident rate is approximately 30%. 1 - 3 Three basic mechanisms lead to cisplatin-induced nephrotoxicity, that is, tubular cell toxicity, renal microvasculature vasoconstriction, and proinflammatory effects. 3 Several factors are associated with increased risk of …
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WebJul 22, 2024 · Cisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in kidney function, as manifested by a decline in the glomerular filtration rate (GFR), can be dose … {{configCtrl2.info.metaDescription}} Nephrotoxicity from chemotherapeutic agents: clinical manifestations, … Ultrafilterable platinum (UP) disposition was studied in 22 cancer patients receiving … The lowest dose categories of cisplatin (≤100 and 101-250 mg/m(2)) are … Faubel S, Ljubanovic D, Reznikov L, et al. Caspase-1-deficient mice are protected … canon c3835i brochureWebSep 27, 2024 · Cisplatin induces cancer cell death by binding to the N7 reactive center of purine residues and causes irreversible DNA damage in cancer cells during division ( Dasari and Tchounwou, 2014 ), thus blocking cell division and promoting apoptosis. canon c5535f ドライバWebFeb 2, 2024 · Some studies have found that vinorelbine protects against cisplatin-induced acute kidney injury (AKI) by activating Nrf2/HO-1 signaling pathway and hindering TLR4-IFN-γ-CD44 cell inflammatory cascade when investigating the molecular mechanism of renal protection against nephrotoxicity (El-Sayed et al., 2024). canon c300 mark 2 hard caseWebThe mechanisms of cisplatin-induced nephrotoxicity are complex and involve multiple pathways and molecules ( Figure 1) [ 92, 93 ]. The cellular pathways of cisplatin injury … canon c100 mark 2 cageWebDiscussion. In a previous study, we showed that DM was the high-risk factor for cisplatin-induced AKI. 5 However, no attempt was made to identify the mechanism for the … canon c5030 waste toner cartridgeWebFeb 2, 2024 · The mechanisms of cisplatin-induced acute kidney injury (AKI) are complex, and there are limited renoprotective approaches. Leonurine is the main active compound of a Chinese herb and has recently been … flag of lima peruWebOct 11, 2024 · Experimentally induced sepsis (via LPS) also potentiates the degree of cisplatin-induced hearing loss in mice (Oh et al., 2011). LPS-induced inflammation in … flag of liguria