WebMay 6, 2024 · A novel class of small proteins, called micropeptides, has recently been discovered in the genome. These proteins, which have been found to play important roles in many physiological and cellular systems, are shorter than 100 amino acids and were overlooked during previous genome annotations. Discovery and characterization of more … WebMar 1, 2024 · DWORF is the only known endogenous peptide that activates SERCA ( Fig. 2 ). It is specifically expressed in heart and muscle cells and localizes to the SR membrane, like MLN. DWORF-Tg mice display significantly higher SERCA activity [ 31, 32].
Inhibitory and Stimulatory Micropeptides Preferentially …
WebJun 16, 2024 · Because of its central importance in physiology, this transporter is tightly controlled by physical interactions with tissue-specific regulatory micropeptides that tune SERCA function to match... WebThe Ca-ATPase isoform 2a (SERCA2a) pumps cytosolic Ca2+ into the sarcoplasmic reticulum (SR) of cardiac myocytes, enabling muscle relaxation during diastole. Abnormally high cytosolic [Ca2+] is a central factor in heart failure, suggesting that augmentation of SERCA2a Ca2+ transport activity could be a promising therapeutic approach. SERCA2a … ironing weave with iron
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WebDec 16, 2024 · Figure 3 Competition of micropeptide hetero-oligomerization and SERCA-binding interactions. (A) SERCA binds to DWORF (red) or PLB (blue) but not both. (B) SERCA binds DWORF and PLB at distinct binding sites. (C) SERCA binds a PLB-DWORF hetero-oligomer. (D) FRET from Cer-DWORF to YFP-PLB with increasing coexpression … WebTenaya Therapeutics WebOct 9, 2024 · The DWORF micropeptide enhances contractility and prevents heart failure in a mouse model of dilated cardiomyopathy. eLife , 2024; 7 DOI: 10.7554/eLife.38319 Cite … ironing white specks